Day 1 :
Keynote: A live imaging nanotechnology: sensing the brain from spectral analysis to neuromolecular imaging to voltaic photonics
Time : 10:00-10:40
Patricia A. Broderick completed her Ph.D. degree in Pharmacology at St. John’s University, College of Arts and Sciences in 1979, a postdoctoral fellowship at the Albert Einstein College of Medicine/Montefiore Hosp., Depts. of Psychiatry and Neuroscience, 1982-1985 and a Research Associate Position at Cornell University, Dept. of Neurology, NY, 1985-1986. Dr. Broderick began her tenured Medical Professorship in CUNY in Fall, 1986 and an Adjunct Professorship in NYU Langone Medical Center, NY, in 2000. In the Broderick Laboratory, Patricia mentors medical doctors, doctoral, masters and post-baccalaureate students in addition to undergraduate students, including top New York high school students. Patricia is the inventor of several patents, held by CUNY and in part by NYU and now held by for manufacturing and worldwide marketing the BRODERICK PROBE®. Vested by , the Company is founded by Dr. Broderick who serves as President of the Board of Directors. Dr. Broderick also serves as Editor-in-Chief (J. , USA), American Field Editor ., Austria/Germany), Academic Editor and Board (, , MDPI, Switzerland/China) and Editorial Boards worldwide such as , Psychology & Psychiatry: Pharmacology; Neurology, London, UK); (, USA/UK). Professor Broderick has published extensively, over 600 publications, demonstrations and presentations, has founded the, and is inventor of the BRODERICK PROBE®, named in honor of her father. The Professor is author of several books including one in press, and Patricia is humble Awardee of numerous prestigious honors, among which, Inner Circle Executives, Acquisitions International Global/Corporate America, International Assc, of Top Professionals, Nat’l Assc Distinguished Professionals. Patricia is honored throughout her career, presently, several front cover magazines globally recognize her work, 2017, 2018 and 2019, “Top 100 Registry Educator” and others list, “Best Biosensor” “Industry Professor”, “Business Woman”, “CUTV Radio & TV Press” and “Empowering Professionals”.
In this fascinating world of sensors, incredibly brilliant sensing devices are conceived for every nanosecond. As a keynote speaker, in the 30th Annual Congress on Nanotechnology and Nanomaterials, I wish to share with you a nanobiosensor, a nano biotechnology that encompasses a biomedical sensing device, smaller than one human hair, successful in sensing exact neuronal transmitters in temporal lobe brain in epilepsy patients, intraoperatively, during surgery performed in NYU Tisch Hospital (IRB Approved). Moreover, live imaging with this nanobiosensor sees precise neuronal release in a genetic animal model of depression, indeed, even as the animal is moving about. Such cutting edge discoveries made possible by the BRODERICK PROBE® Nanobiosensors have changed the way that scientists and medical doctors have viewed the brain, its function, dysfunction and treatments, pharmaceutical and/ or neurosurgical. We can see inside the living brain online and in vivo. Therefore, this sleek nanobiosensor, BRODERICK PROBE®, a polymeric neuroprobe, is designed to diagnose and treat debilitating neurodegenerative and psychiatric brain disorders. This keynote focusses on this unique series of nanobiosensors specifically as miniature nanosurgical biomedical devices for epilepsy, Parkinson’s and affective disorders. NYU pathologists and immunologists report that the sensor does not cause gliosis (scars) nor does it promote bacterial growth with or without sterilization. I began this journey as a neuroscientist and transformed spectrometry into spectral analysis in the form of live electrochemistry using carbon allotropes in lipid matrices. Then, the journey led me into video tracking with neuromolecular imaging and now into voltaic photonics, using protein neuroprobes in dual photodiode/fiber optics.The nanobiosensor operates by detecting current at potential differences, experimentally specific for each neurotransmitter. Several neuromolecules are imaged selectively within subseconds in real time, in vivo, in vitro and in situ. What we have here, in one example, is a miniature biocompatible, photosensitive, electroactive polymeric sensing neuroprobe that operates by converting photonic energy into electrochemical energy, generating a photocurrent in the brain via ion channels in skull without opening the brain and/or opening the brain minimally. The output is provided in units of voltage. Laser diodes encompassing fiber optic proteins enable the electrochemical waveform to be seen as an electrochemical image. The photocurrent provides an imaging profile of neurochemicals derived from sensing the brain. Thus, our original BRODERICK PROBE® polymer, a nano biotechnology that sees inside the brain, is further enabled by quantum mechanics inventive art for advanced nanomedicine and nanosurgical sensing devices in the BRODERICK PROBE®. This photoelectrochemical conductance device provides another novel series of nanobiosensors for nano biotechnology, nano-diagnostics, nanotherapies and nanotheranostics.
Saha Institute of Nuclear Physics
If alkali metals such as Cs, Li, Rb, K, Na, etc. (referred as A in general) are present in the neighborhood of the probing element (M) on a sample surface, quasi-molecular ions can be formed by the attachment of these alkali ions [(MA)+ formation] in the secondary ion mass spectrometry (SIMS) process. Formation of these MA+ molecular ions has a strong correlation to the atomic polarizability of the element M. The emission process for the re-sputtered species M0 is decoupled from the MA+ ion formation process, in analogy with the ion formation in secondary neutral mass spectrometry (SNMS), resulting in a drastic decrease in the conventional ‘matrix effect’ in SIMS. Although the detection of MA+ molecular ions in SIMS has found its applicability in direct materials quantification, it generally suffers from a low useful yield. In such cases, detection of (MA)n+ (n=2, 3,….) molecular ions offers a much better sensitivity (even by several orders of magnitude), as the yields of such molecular ion complexes have often been found to be higher than that of MA+ ions. The recombination coefficient of MA+ or MA2+ molecular species depends on the electro-positivity or electro-negativity of the element M, respectively. Apart from the surface binding energy of the respective uppermost monolayer, the changes in local surface work-function have often been found to play a significant role in the emission of these molecular ions. Although these MAn+ molecular-ion based SIMS has great relevance in the analysis of materials, a complete understanding on the formation mechanisms of these ion-complexes is still lacking.
A procedure, based on MAn+-SIMS approach, has been proposed for the accurate germanium quantification in Molecular Beam Epitaxy (MBE)-grown Si1−xGex alloys. The ‘matrix effect’ has been shown to be completely suppressed for all Ge concentrations irrespective of impact Cs+ ion energies. Cesium, the fifth alkali element, is the most reactive of all the metals. The methodology has successfully been applied for direct quantitative composition analysis of various thin film and multilayer structures. Recent study on various ZnO-based nanostructures has successfully been correlated to their photo-catalysis and photoemission responses. The talk will address the various possible formation mechanisms of MCsn+ molecular ion complexes in sputtering process and the fascinating applications of the MCsn+-SIMS approach for the interfacial analysis of ultra-thin films, superlattices, quantum wells, etc. and for compositional analysis of MBE - grown Si1-xGex alloy structures.