Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 8th World Congress on Spectroscopy and Analytical Techniques Quality Hotel Globe | Stockholm, Sweden.

Day 1 :

Conference Series Euro Spectroscopy 2018 International Conference Keynote Speaker Patricia Ann Broderick photo
Biography:

Patricia A. Broderick completed her Ph.D. degree in Pharmacology at St. John’s University, College of Arts and Sciences in 1979, a postdoctoral fellowship at the Albert Einstein College of Medicine/Montefiore Hosp., Depts. of Psychiatry and Neuroscience, 1982-1985 and a Research Associate Position at Cornell University, Dept. of Neurology, NY, 1985-1986. Dr. Broderick began her tenured Medical Professorship in CUNY in Fall, 1986 and an Adjunct Professorship in NYU Langone Medical Center, NY, in 2000. In the Broderick Laboratory, Patricia mentors medical doctors, doctoral, masters and post-baccalaureate students in addition to undergraduate students, including top New York high school students. Patricia is the inventor of several patents, held by CUNY and in part by NYU and now held by Eazysense Nanotechnologies Inc, for manufacturing and worldwide marketing the BRODERICK PROBE®. Vested by Indian Angel Network®, the Company is founded by Dr. Broderick who serves as President of the Board of Directors. Dr. Broderick also serves as Editor-in-Chief (J. Biochips & Tissue Chips, USA), American Field Editor (J. Neural Transm., Austria/Germany), Academic Editor and Board (SensorsBrain Sciences, MDPI, Switzerland/China) and Editorial Boards worldwide such as (E Cronicon, Psychology & Psychiatry: Pharmacology; Neurology, London, UK); (MOJ Medcrave, Clinical and Medical Cases, USA/UK). Professor Broderick has published extensively, over 600 publications, demonstrations and presentations, has founded the Broderick Brain Foundation, and is inventor of the BRODERICK PROBE®, named in honor of her father. The Professor is author of several books including one in press, Neuroimaging-Nanosensing Biochemistry in Brain (Pan Stanford Publishing Pte. Ltd, Singapore)  and Patricia is humble Awardee of numerous prestigious honors, among which, Inner Circle Executives, Acquisitions International Global/Corporate America, International Assc, of Top Professionals, Nat’l Assc Distinguished Professionals. Patricia is honored throughout her career, presently, several front cover magazines globally recognize her work, 2017, 2018 and 2019, “Top 100 Registry Educator” and others list, “Best Biosensor” “Industry Professor”, “Business Woman”, “CUTV Radio & TV Press”  and “Empowering Professionals”.

Abstract:

In this fascinating world of sensors, incredibly brilliant sensing devices are conceived for every nanosecond. As a keynote speaker, in the 30th Annual Congress on Nanotechnology and Nanomaterials, I wish to share with you a nanobiosensor, a nano biotechnology that encompasses a biomedical sensing device, smaller than one human hair, successful in sensing exact neuronal transmitters in temporal lobe brain in epilepsy patients, intraoperatively, during surgery performed in NYU Tisch Hospital (IRB Approved). Moreover, live imaging with this nanobiosensor sees precise neuronal release in a genetic animal model of depression, indeed, even as the animal is moving about. Such cutting edge discoveries made possible by the BRODERICK PROBE® Nanobiosensors have changed the way that scientists and medical doctors have viewed the brain, its function, dysfunction and treatments, pharmaceutical and/ or neurosurgical. We can see inside the living brain online and in vivo. Therefore, this sleek nanobiosensor, BRODERICK PROBE®, a polymeric neuroprobe, is designed to diagnose and treat debilitating neurodegenerative and psychiatric brain disorders. This keynote focusses on this unique series of nanobiosensors specifically as miniature nanosurgical biomedical devices for epilepsy, Parkinson’s and affective disorders. NYU pathologists and immunologists report that the sensor does not cause gliosis (scars) nor does it promote bacterial growth with or without sterilization. I began this journey as a neuroscientist and transformed spectrometry into spectral analysis in the form of live electrochemistry using carbon allotropes in lipid matrices. Then, the journey led me into video tracking with neuromolecular imaging and now into voltaic photonics, using protein neuroprobes in dual photodiode/fiber optics.The nanobiosensor operates by detecting current at potential differences, experimentally specific for each neurotransmitter. Several neuromolecules are imaged selectively within subseconds in real time, in vivo, in vitro and in situ. What we have here, in one example, is a miniature biocompatible, photosensitive, electroactive polymeric sensing neuroprobe that operates by converting photonic energy into electrochemical energy, generating a photocurrent in the brain via ion channels in skull without opening the brain and/or opening the brain minimally. The output is provided in units of voltage. Laser diodes encompassing fiber optic proteins enable the electrochemical waveform to be seen as an electrochemical image. The photocurrent provides an imaging profile of neurochemicals derived from sensing the brain. Thus, our original BRODERICK PROBE® polymer, a nano biotechnology that sees inside the brain, is further enabled by quantum mechanics inventive art for advanced nanomedicine and nanosurgical sensing devices in the BRODERICK PROBE®. This photoelectrochemical conductance device provides another novel series of nanobiosensors for nano biotechnology, nano-diagnostics, nanotherapies and nanotheranostics.

 

Conference Series Euro Spectroscopy 2018 International Conference Keynote Speaker Purushottam Chakraborty photo
Biography:

Purushottam Chakraborty is considered India’s one of the most prominent figures in the field of Spectrometry, he is one of the world’s leading experts in SIMS. He has published more than 150 scientific papers impacting the discipline through vast knowledge. He has given lectures over 130 countries including Invited talks and Chaired Sessions across the globe. Honored with numerous awards, including the "Most eminent Mass Spectrometrist of India" in 2003 is most significant one among many.

Abstract:

If alkali metals such as Cs, Li, Rb, K, Na, etc. (referred as A in general) are present in the neighborhood of the probing element (M) on a sample surface, quasi-molecular ions can be formed by the attachment of these alkali ions [(MA)+ formation] in the secondary ion mass spectrometry (SIMS) process. Formation of these MA+ molecular ions has a strong correlation to the atomic polarizability of the element M. The emission process for the re-sputtered species M0 is decoupled from the MA+ ion formation process, in analogy with the ion formation in secondary neutral mass spectrometry (SNMS), resulting in a drastic decrease in the conventional ‘matrix effect’ in SIMS. Although the detection of MA+ molecular ions in SIMS has found its applicability in direct materials quantification, it generally suffers from a low useful yield. In such cases, detection of (MA)n+ (n=2, 3,….) molecular ions offers a much better sensitivity (even by several orders of magnitude), as the yields of such molecular ion complexes have often been found to be higher than that of MA+ ions. The recombination coefficient of MA+ or MA2+ molecular species depends on the electro-positivity or electro-negativity of the element M, respectively. Apart from the surface binding energy of the respective uppermost monolayer, the changes in local surface work-function have often been found to play a significant role in the emission of these molecular ions. Although these MAn+ molecular-ion based SIMS has great relevance in the analysis of materials, a complete understanding on the formation mechanisms of these ion-complexes is still lacking.

 

A procedure, based on MAn+-SIMS approach, has been proposed for the accurate germanium quantification in Molecular Beam Epitaxy (MBE)-grown Si1−xGex alloys. The ‘matrix effect’ has been shown to be completely suppressed for all Ge concentrations irrespective of impact Cs+ ion energies. Cesium, the fifth alkali element, is the most reactive of all the metals. The methodology has successfully been applied for direct quantitative composition analysis of various thin film and multilayer structures. Recent study on various ZnO-based nanostructures has successfully been correlated to their photo-catalysis and photoemission responses. The talk will address the various possible formation mechanisms of MCsn+ molecular ion complexes in sputtering process and the fascinating applications of the MCsn+-SIMS approach for the interfacial analysis of ultra-thin films, superlattices, quantum wells, etc. and for compositional analysis of MBE - grown Si1-xGex alloy structures. 

  • Cancer Nanotechnology | Ceramic and Glass Materials | Future of Nanotechnology | Graphene Technology | Green Nanotechnology | MEMS & NEMS | Microtechnology | Multifunctional Nanobiomaterials | Nano Coatings | Nano Electronics | Nano Medicine | Nano Toxicology | Polymer Chemistry | Quantum Dots | Nano Sensors | Nano Robotics | Nano Photonics and Optics | Nano Pharmaceutical | Nanosponges | Nanotechnology The Future Path | Spectroscopy tools in Nanotechnology

Session Introduction

Luiz Cesar Martini

State University of Campinas, Brazil

Title: Theoretical formulas of the elementary particles in the scope of nanoparticles and nanotechnologyy

Time : 11:30-12:00

Biography:

Luiz Cesar Martini is currently working as a Professor at the Faculty of Electrical and Computer Engineering, State University of Campinas, City of Campinas- São Paulo-Brazil. He received his Postgraduate degree at State University of Campinas, Brazil in 1989. After spending great effort since 1977 creating and developing the "Dimensional Continuous Space-Time Theory", relating time and space, he completed it successfully in 2005 and published some results in 2013-2014

Abstract:

This lecture, within the scope of nanoparticles, will present the theoretical formulas of particles elemental proton, electron and neutron based on the fundamental equation of the continuous time space published in the book by Gaol F L, Shrivastava K N, Akhtar J, Martini Luiz Cesar, Introducing the Dimensional Continuous Space-Time Theory in “Recent Trends in Physics of Material Science and Technology” Series. The fundamental dimensional equation of continuous time space allows to explain many physical phenomena related to nanotechnology, deducing theoretical speed of light in the empty space, mass of particles elementary, periodic table, formation of orbitals, wave duality particle, etc., as well as the macroscopic phenomena of formation of the universe and characterization and equation of time and space.

Biography:

Mei Liu received his Master degree from School of Biological Science and Medical Engineering, Southeast University in 2017, and is now a PhD student in Southeast University. His research interests include aptamer selection, nucleic acid nanotechnology and their applications for the diagnosis and therapy of cancer. He has published six SCI papers eight as first author or co-author.

Abstract:

Breast cancer is a highly heterogeneous tumor with four major molecular subtypes, which has become the second leading cause of death among women
in the world. In clinic medicine, different breast cancer subtypes show distinct
response to the therapy and prognosis and the molecular classification of breast
cancer remain a challenge, which depend on highly specific molecular probes. In this study, a ssDNA aptamer with high specificity and binding affinity to SK-BR-3 cells was obtained by Cell-SELEX method. Followed in vitro studies demonstrated that the aptamer can not only distinguish SK-BR-3 breast cancer cell line from MDA-MB-231, MCF-7 breast cancer cell lines and MCF-10A human normal mammary epithelial cell line, but also can differentiate HER2-positive breast cancer tissues from Luminal A, Luminal B, triple-negative breast cancer tissues and adjacent normal breast tissues, indicating its great potential for the molecular classification of breast cancer subtypes. Moreover, the in vivo experiments of the aptamer also demonstrated its good targeting ability against tumor-bearing mice of SK-BR-3 breast cancer cells. All these results demonstrated that the aptamer could be further developed into a novel molecular probe for the precise diagnosis and a highly effective biological missile for the targeted therapy of breast cancer.

Biography:

Carla I P Aguilar is an Engineer. She has completed four Master’s Degrees’ in Manufacturing Engineering, MBA, Finance and Environment. She has also four specializations in Management, Groundwater Modelling, Energy, Water Quality and Bio-indicators, and multiple courses in various engineering and management fields worldwide. She did her research at Ècole des Mines de Paris for 10 years in special techniques and economics in sub-soil exploitations. Currently, she is a PhD candidate at University of Central Florida. She has participated in exhibitions and as speaker in various conferences around the world for many years. She has also published various papers in topics such as: agriculture, remote sensing, modelling and land used optimization are among others. She has been a Consultant for various companies in Colombia-South America and at international level. She has also been widely involved in social work and sustainable development.

Abstract:

The two applications that used clays with particular sizes from 3 Å to 5 Å were
implemented in the dehydration of food and in ballast water treatment. The former allowed the concentration of vitamins, augmentation of inulin content, improvement of probiotics’ bacteria count and preservation of more than 1000 products for periods longer than one year without employing chemicals. The latter contributed to destroy bacteria in ballast water and also to remove seawater in oil by products and recover their characteristics to be reused for the same application or as a lower grade product; important outcome especially during oil spills. The process consists of using clays as filters in a vacuum chamber and tuning the changes of temperature and pressure by trial and error until the maximization of desired characteristics is obtained. Results showed that vitamin content could increase at least five times more than the natural product for the same analyzed quantity, for inulin content three times more and probiotics’ bacteria count up to five times more. For ballast water, with initial count at 1:1 dilution, 8 cells/g were found; after the clay nano-filter process at 1:100 dilutions, less than 100 cells/g were counted. For seawater and sediments at 1:100 dilutions before the treatment 1200 cells/g were found, while after the process at the same dilution, only 100 cells/g were counted. For the oil based components, different viscosities and seawater mixes of 50%-50% and 25% oil and 75% seawater were tested in a 12- hour and 24-hour cycle. Water removal results between 65%-80%. The viscosities and seawater removal of the three studied oil based components determined the final applications.

Biography:

Z Li is currently a PhD student at School of Civil and Environmental Engineering, Nanyang Technological University, Singapore. He joined Prof. Darren Sun’s group in 2015. His re-search focuses on fabrication and application of bio-inspired super-hydrophilic materials

Abstract:

Oil contaminated wastewater from industry and oil spills threatens our environment and sustainable development. Conventional separation methods are suffering from several limitations. Membrane technology as well as nano-technology shows great potential in oil-water separation. Inspired by the stomata of leaves, a smart photo-sensitive hierar-chical nano-fibrous membrane was success-fully fabricated by a facile and highly effec-tive method with the combination of elec-trospinning and hydrothermal reaction in this research. ZnO nanorods can easily grow on the electrospun PSF nanofibers to form three-dimensional hierarchical structure with large specific surface area by hydrothermal reaction. Due to the photo-sensitivity of ZnO nanorods, without UV light, the surface is super-hydrophobic and air gaps in the pores will prevent the passage both of water and oil, while under UV light irrita-tion, the surface becomes super-hydrophilic and water will be able to pass through the membrane leaving oil at the other side. This photo-responsive nano-fibrous membrane shows excellent performance for oil-water separation.

Brahamdutt Arya

CSIR- National Physical Laboratory, India Academy of Scientific and Innovative Research, India

Title: Graphene oxide-chloroquine induced p62/SQSTM1 mediated necroptotic cell death in A549 lung cancer cells
Biography:

Brahamdutt Arya is currently pursuing his Doctoral Degree under the supervision of Dr. Surinder P Singh at CSIR-National Physical Laboratory, New Delhi, India. He received his Bachelor’s Degree in Chemistry Honors from MDU, Rohtak, India and Master’s Degree with specialization in Organic Chemistry from University of Delhi, New Delhi, India. At present, he is working on the fabrication of gold and graphene oxide based on multifunctional nanomaterials and exploring their applications in bio imaging, drug delivery, and photothermal therapy for development of targeted and personalized nanomedicines. Also, he is developing the Indian National Standard for the gold nanoparticles.

Abstract:

Graphene oxide (GO) alters the autophagy response through toll like receptor
signaling, lysosomal dysfunction, mitochondrial destabilization and NF-κB
pathways. On the other hand, chloroquine (Chl) an FDA approved drug inhibits
the autophagy and has also shown anticancer potential. In the present study, we
endeavored to conjugate Chl with highly exfoliated GO nanosheets and test its
antiproliferative activity on A549 lung cancer and BEAS-2B normal lung cell lines respectively. Morphological parameters have been analyzed through HRTEM, FESEM and AFM techniques. Also, TEM has been employed for analysis ofcellular components on exposure of GO-Chl nanoconjugate. Further, structural,functional and optical properties of GO, Chl and GO-Chl have been investigated using Raman, FTIR and UV-Vis spectroscopy respectively. MTT assay has been performed for in-vitro cytotoxicity evaluation of GO, Chl and GO-Chl exposure on A549 and BEAS-2B cell lines and demonstrated that GO-Chl treatment exhibits significant cell death in A549 lung cancer cells, in contrast to an almost 90% cell survival in normal BEAS-2B cells. The flow cytometric and DCFDA assay reveals that GO-Chl has been internalized through clathrin mediated endocytosis mechanism and indicates enhanced level of ROS. Further, the autophagy response in A549 cells due to GO-Chl treatment is investigated through fluorescence
microscopic analysis (MDC staining and GFP-LC3 plasmid), TEM observations and immunoblot analysis. Enhanced level of LC-3 I/II and Atg-5 markers signifies the autophagosomes formation and elevated expression of p62/SQSTM1 indicates the inhibition of autophagy at later stage. The co-immunoprecipitation assay
reveals necroptotic cell death in A549 cell lines on exposure of GO-Chl.