Spectroscopy and Analytical Techniques

Biography

Biography: Patricia Ann Broderick

Abstract

In this fascinating world of sensors, incredibly brilliant sensing devices are conceived for every nanosecond. As a keynote speaker, in the 30th Annual Congress on Nanotechnology and Nanomaterials, I wish to share with you a nanobiosensor, a nano biotechnology that encompasses a biomedical sensing device, smaller than one human hair, successful in sensing exact neuronal transmitters in temporal lobe brain in epilepsy patients, intraoperatively, during surgery performed in NYU Tisch Hospital (IRB Approved). Moreover, live imaging with this nanobiosensor sees precise neuronal release in a genetic animal model of depression, indeed, even as the animal is moving about. Such cutting edge discoveries made possible by the BRODERICK PROBE® Nanobiosensors have changed the way that scientists and medical doctors have viewed the brain, its function, dysfunction and treatments, pharmaceutical and/ or neurosurgical. We can see inside the living brain online and in vivo. Therefore, this sleek nanobiosensor, BRODERICK PROBE®, a polymeric neuroprobe, is designed to diagnose and treat debilitating neurodegenerative and psychiatric brain disorders. This keynote focusses on this unique series of nanobiosensors specifically as miniature nanosurgical biomedical devices for epilepsy, Parkinson’s and affective disorders. NYU pathologists and immunologists report that the sensor does not cause gliosis (scars) nor does it promote bacterial growth with or without sterilization. I began this journey as a neuroscientist and transformed spectrometry into spectral analysis in the form of live electrochemistry using carbon allotropes in lipid matrices. Then, the journey led me into video tracking with neuromolecular imaging and now into voltaic photonics, using protein neuroprobes in dual photodiode/fiber optics.The nanobiosensor operates by detecting current at potential differences, experimentally specific for each neurotransmitter. Several neuromolecules are imaged selectively within subseconds in real time, in vivo, in vitro and in situ. What we have here, in one example, is a miniature biocompatible, photosensitive, electroactive polymeric sensing neuroprobe that operates by converting photonic energy into electrochemical energy, generating a photocurrent in the brain via ion channels in skull without opening the brain and/or opening the brain minimally. The output is provided in units of voltage. Laser diodes encompassing fiber optic proteins enable the electrochemical waveform to be seen as an electrochemical image. The photocurrent provides an imaging profile of neurochemicals derived from sensing the brain. Thus, our original BRODERICK PROBE® polymer, a nano biotechnology that sees inside the brain, is further enabled by quantum mechanics inventive art for advanced nanomedicine and nanosurgical sensing devices in the BRODERICK PROBE®. This photoelectrochemical conductance device provides another novel series of nanobiosensors for nano biotechnology, nano-diagnostics, nanotherapies and nanotheranostics.